Therefore, the objective of this study was to evaluate the efficacy and safety of large-scale and long-term AGA treatment with finasteride, which, to our knowledge, is the first of such studies in Japan. Although the efficacy of AGA treatment with finasteride has been demonstrated by several large-scale and long-term studies, no long-term investigation for up to 10 years has yet been conducted in Japanese subjects.
Dihydro-testosterone (DHT) has a key role in mediating progressive scalp hair loss in men with AGA, and finasteride blocks the conversion of testosterone to DHT as a selective type II 5α-reductase inhibitor, which justifies its use in AGA treatment. Presently, finasteride is authorized in over 60 countries and is administered to over 3 million patients for AGA. Key wordsĪndrogenetic alopecia, finasteride, Japanese, long-term, modified global photographic assessment, Norwood-Hamilton scale Introductionįinasteride was authorized in Japan for the treatment of androgenetic alopecia (AGA) in 2005 subsequently, prescription of this medication commenced. Long-term (10-year) treatment with 1 mg/day finasteride in Japanese men with androgenetic alopecia showed high efficacy in subjective and objective evaluations. During the study period, no serious adverse reaction was recognized. Furthermore, the quantitative analysis of the objective evaluation using the questionnaire was also significantly different (P<0.001). The groups that showed Norwood-Hamilton: I/II/III and IV/V/VI/VII at the first visit showed statistically significant differences in the modified global photographic assessment score at the 10-year treatment subjective evaluation (6.27 ± 0.62 vs 5.52 ± 0.78, P<0.001). The Norwood-Hamilton classification grading improved by approximately 1 grade from 3.35 ± 1.11 to 2.55 ± 1.30 after the 10-year treatment. The proportions of patients with improvement (score ≥ 5) and prevention of disease progression (score ≥ 4) were 91.5% and 99.1%, respectively. For the Norwood-Hamilton classifications, stages IIa and IIv were combined as II, IIIa and IIIv were combined as III, IVa was combined as IV, and Va was combined as V. The efficacy was assessed using the Norwood-Hamilton scale and modified global photographic assessment score, the standardized 7-point rating score using scalp photographs. We performed subjective evaluations, using questionnaires administered to patients, in addition to the objective evaluation by doctors. Therefore, we evaluated the efficacy and safety of 1 mg/day finasteride in 532 Japanese men who were treated for androgenetic alopecia for 10 years. Finasteride is a standard medical treatment for androgenetic alopecia however, no long-term study of up to 10 years has been performed in Japan.
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